Side Reactions in Peptide Synthesis

Based on the author's academic and industrial experience and backed by a thorough review of the current literature, Side Reactions in Peptide Synthesis provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay of progress. This unique resource gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the referred side reactions. To enable use and navigation, side reactions are categorized by their peptide sequences and/or synthetic routes. This comprehensive resource covers solid phase and solution phase methodologies, and includes abundant references for further exploration. As the market share of peptides and peptidomimetics as active pharmaceutical ingredients (APIs) is steadily increasing, Side Reactions in Peptide Synthesis answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Features systematic examination of the most frequent side reactions in peptide synthesis; optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production; and thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists.