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This book provides a comprehensive overview of psoriasis as a systemic inflammatory disease, exploring its wide-ranging comorbidities and evolving therapeutic approaches. In addition to cardiovascular complications and metabolic syndrome, it examines associations with malignancies, Crohn's disease, psychiatric disorders, and special patient populations, including renal transplant recipients and dialysis patients. Unique chapters address the skin barrier, psoriasis during pregnancy, and emerging treatment strategies. The latest developments in biologics and biosimilars are presented alongside alternative and less commonly used therapeutic options, including rifampicin-based approaches. The volume also highlights historical and contemporary perspectives on concepts such as the "psoriatic heart" and recognizes significant contributions of the Bulgarian dermatological school in psoriasis research, including studies on drug-induced psoriasis, climatotherapy, and innovative treatments. This work is an essential reference for dermatologists, clinicians, and researchers seeking a deeper understanding of psoriasis beyond its cutaneous manifestations.
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